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NLRP3 inflammasome in endothelial dysfunction

Animal data indicates rapid clearance typical of unmodified small peptides, generally minutes to low hours in plasma

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Prednisolone Sodium Phosphate Oral Solution (10 mg Prednisolone per 5 mL), Prednisolone Sodium Phosphate Oral Solution (15 mg Prednisolone per 5 mL), Prednisolone Sodium Phosphate Oral Solution (20 mg Prednisolone per 5 mL) and Prednisolone Sodium Phosphate (25 mg Prednisolone per 5 mL) produce a 14% higher peak plasma level of prednisolone which occurs 20% faster than that seen with tablets

Cancer Res 61(18):66496655 Huang X et al (2010) Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion